Nash Theodore E, Bustos Javier A, Garcia Hector H
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Unidad de Cisticercosis, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Trends Parasitol. 2017 Jan;33(1):65-73. doi: 10.1016/j.pt.2016.09.003. Epub 2016 Oct 4.
Taenia solium (the pork tapeworm) is present in most developing countries, where it is a frequent cause of seizures and other neurological disease. Parasitic larvae invade the human brain, establish, and eventually resolve, leaving a calcified scar. While these lesions are common in endemic regions, and most of these are clinically silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions, and 30-65% of these cases are associated with perilesional edema (PE), likely due to host inflammation. This manuscript summarizes the importance, characteristics, natural history, and potential prevention and treatments of symptomatic calcified neurocysticercosis (NCC).
猪带绦虫(猪肉绦虫)在大多数发展中国家都有出现,是引发癫痫和其他神经系统疾病的常见病因。寄生虫幼虫侵入人脑,寄生并最终消失,留下钙化疤痕。虽然这些病变在流行地区很常见,且大多数临床上并无症状,但一部分有钙化囊尾蚴的个体因这些病变会引发癫痫,其中30%-65%的病例与病灶周围水肿(PE)有关,这可能是由于宿主炎症引起的。本文总结了有症状的钙化性神经囊尾蚴病(NCC)的重要性、特征、自然病史以及潜在的预防和治疗方法。