开发改良型低氧细胞放射增敏剂的基本原理。
The rationale for the development of improved hypoxic cell radiosensitizers.
作者信息
Wardman P, Clarke E D, Flockhart I R, Wallace R G
出版信息
Br J Cancer Suppl. 1978 Jun;3:1-5.
Abstract
This paper outlines the chemical background to the selection of compounds likely to be clinically superior to the nitroimidazoles currently being evaluated in cancer therapy. The most important chemical properties to consider are electron affinity and lipophilicity, and the quantification and prediction of both these properties are considered. Examples are presented of the use of multiple regression analysis to evaluate the relative contribution of individual properties to the overall biological response.
摘要
本文概述了选择可能在临床上优于目前癌症治疗中正在评估的硝基咪唑类化合物的化学背景。需要考虑的最重要的化学性质是电子亲和力和亲脂性，并对这两种性质的量化和预测进行了探讨。文中给出了使用多元回归分析来评估各个性质对整体生物学反应的相对贡献的示例。
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The rationale for the development of improved hypoxic cell radiosensitizers.开发改良型低氧细胞放射增敏剂的基本原理。
Br J Cancer Suppl. 1978 Jun;3:1-5.
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引用本文的文献
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Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.乏氧细胞放射增敏剂去甲基米索硝唑（Ro 05-Ro-9963）在犬体内的药代动力学及肿瘤穿透特性
Br J Cancer. 1980 Feb;41(2):268-76. doi: 10.1038/bjc.1980.39.
本文引用的文献
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Nitroimidazole derivatives. Relationship between structure and antitrichomonal activity.硝基咪唑衍生物。结构与抗滴虫活性之间的关系。
J Med Chem. 1967 Sep;10(5):891-7. doi: 10.1021/jm00317a030.
2
Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria.电子亲和致敏作用。I. 细菌中化学放射增敏剂的结构基础。
Int J Radiat Biol Relat Stud Phys Chem Med. 1969 Jul;15(5):457-71. doi: 10.1080/09553006914550741.
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Lipophilic character and biological activity of drugs. II. The parabolic case.
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Linear relationships between lipophilic character and biological activity of drugs.药物的亲脂性特征与生物活性之间的线性关系。
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5
Radiosensitization of mammalian cells by p-nitroacetophenone. 3. Effectiveness of nitrobenzene analogues.
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6
Radiosensitization of mammalian cells by p-nitroacetophenone. II. Effectiveness of analogues.对硝基苯乙酮对哺乳动物细胞的放射增敏作用。II. 类似物的有效性。
Int J Radiat Biol Relat Stud Phys Chem Med. 1972 May;21(5):475-82. doi: 10.1080/09553007214550551.
7
Letter: Correlation of the efficiencies of some radiation sensitizers and their redox potentials.信函：某些辐射增敏剂的效率与其氧化还原电位的相关性。
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Jul;26(1):87-90. doi: 10.1080/09553007414551001.
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Mammalian cell toxicity of nitro compounds : dependence upon reduction potential.
Biochem Biophys Res Commun. 1976 Oct 4;72(3):824-9. doi: 10.1016/s0006-291x(76)80207-0.
9
10
The use of nitroaromatic compounds as hypoxic cell radiosensitizers.硝基芳香化合物作为低氧细胞放射增敏剂的应用。
Curr Top Radiat Res Q. 1977 Aug;11(4):347-98.
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