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2-硝基咪唑类药物米索硝唑（Ro-07-0582）对小鼠体内集落形成单位的毒性和放射增敏作用。

Toxic and radiosensitizing effect of the 2-nitroimidazole misonidazole (Ro-07-0582) on murine CFU in vivo.

作者信息

Pettersen E O

出版信息

Br J Cancer Suppl. 1978 Jun;3:107-10.

PMID:277208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149398/
Abstract

Spleen colony-forming stem cells of the bone marrow of mice (CFU) have been used as an in vivo test system for toxic and radiosensitizing effects of misonidazole. The cells were irradiated in vivo in the donors before they were suspended and injected i.v. into recipients. Hyoxic conditions were achieved by killing the donors 20 min before irradiation. A drug dose in donors of 1.0 mg/g body wt (ca 1200 microgram/ml in serum) was found to be weakly toxic over an exposure time of 50 min under hypoxic conditions. The radiosensitizing effect at this concentration was found to be about the same as the full effect of oxygen.

摘要

小鼠骨髓的脾集落形成干细胞（CFU）已被用作米索硝唑毒性和放射增敏作用的体内测试系统。在将这些细胞悬浮并静脉注射到受体之前，先在供体内进行体内照射。通过在照射前20分钟处死供体来实现低氧条件。发现在低氧条件下暴露50分钟的情况下，供体中1.0毫克/克体重的药物剂量（血清中约1200微克/毫升）具有微弱毒性。发现该浓度下的放射增敏作用与氧气的完全作用大致相同。

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引用本文的文献

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Br J Cancer. 1979 Nov;40(5):761-7. doi: 10.1038/bjc.1979.258.

本文引用的文献

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Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.亲电子致敏作用。V. 某些硝基咪唑和硝基吡唑对缺氧细菌和哺乳动物细胞的体外放射致敏作用
Radiat Res. 1974 Oct;60(1):108-18.
2
X-ray inactivation of murine bone marrow cells as measured by the spleen colony assay and the diffusion chamber technique.通过脾集落试验和扩散盒技术测定的小鼠骨髓细胞的X射线灭活。
Radiat Res. 1974 Jun;58(3):409-16.
3
The f number of primary transplanted splenic colony-forming cells.初次移植的脾集落形成细胞的f值。
Cell Tissue Kinet. 1971 May;4(3):217-23. doi: 10.1111/j.1365-2184.1971.tb01532.x.
4
Radiosensitization of C3H mouse mammary tumours using fractionated doses of x rays with the drug Ro-07-0582.使用药物Ro-07-0582和分次剂量X射线对C3H小鼠乳腺肿瘤进行放射增敏
Br J Radiol. 1976 Jan;49(577):76-80. doi: 10.1259/0007-1285-49-577-76.
5
The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.可移植肿瘤对分次照射的反应。1. X射线与乏氧细胞放射增敏剂Ro-07-0582
Radiat Res. 1976 Apr;66(1):66-75.
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