通过酰基分子内迁移过程将烯酰胺高效转化为α-酰氧基酮的新方法。
Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process.
作者信息
Zhou Xiaoqiang, Ma Haojie, Cao Jinhui, Liu Xingxing, Huang Guosheng
机构信息
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, 730000, China.
出版信息
Org Biomol Chem. 2016 Oct 25;14(42):10070-10073. doi: 10.1039/c6ob02002j.
Hydrogen peroxide and anhydride mediated transformation of enamides to afford substituted α-acyloxy ketones is described. This transition-metal-free cascade reaction has a broad substrate scope and high efficiency. The acyl intramolecular migration procedure successfully achieved this acyloxylation process under mild conditions and increased the atom efficiency.
描述了过氧化氢和酸酐介导的烯酰胺转化以提供取代的α-酰氧基酮。这种无过渡金属的串联反应具有广泛的底物范围和高效率。酰基分子内迁移过程在温和条件下成功实现了这种酰氧基化过程，并提高了原子效率。
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