Trinh Khang H, Nguyen Khang X, Pham Phuc H, Nguyen Tung T, Phan Anh N Q, Phan Nam T S
Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT) 268 Ly Thuong Kiet, District 10 Ho Chi Minh City Vietnam
Vietnam National University Ho Chi Minh City Linh Trung Ward, Thu Duc District Ho Chi Minh City Vietnam.
RSC Adv. 2020 Aug 13;10(50):29900-29909. doi: 10.1039/d0ra05040g. eCollection 2020 Aug 10.
An efficient metal-free synthesis of 2,4-substituted quinazolines a hydrogen peroxide-mediated one-pot three-component reaction of 2-aminoaryl ketones, aldehydes, and ammonium acetate has been developed. The transformation proceeded readily under mild conditions in the presence of commercially available hydrogen peroxide. The significant advantages of this approach are (1) the readily available atom-efficient and green hydrogen peroxide as oxidant; (2) no transition metal catalyst is required; (3) mild reaction conditions; and (4) wide substrate scope. To the best of our knowledge, utilizing hydrogen peroxide as an atom-efficient and green oxidant for the synthesis of 2,4-substituted quinazolines has not previously been reported in the literature. This method is complementary to previous protocols for the synthesis of 2,4-substituted quinazolines.
已开发出一种高效的无金属合成2,4-二取代喹唑啉的方法，即2-氨基芳基酮、醛和乙酸铵的过氧化氢介导的一锅三组分反应。在市售过氧化氢存在下，该转化反应在温和条件下易于进行。该方法的显著优点包括：（1）使用易于获得的原子经济且绿色的过氧化氢作为氧化剂；（2）无需过渡金属催化剂；（3）反应条件温和；（4）底物范围广泛。据我们所知，此前文献中尚未报道过利用过氧化氢作为原子经济且绿色的氧化剂来合成2,4-二取代喹唑啉。该方法是对先前合成2,4-二取代喹唑啉方法的补充。
