鼠疫耶尔森菌研究视角：一种研究人畜共患病原体的模型

Perspectives on Yersinia pestis: A Model for Studying Zoonotic Pathogens.

作者信息

Yang Ruifu, Cui Yujun, Bi Yujing

机构信息

Beijing Institute of Microbiology and Epidemiology, No. 20, Dongdajie, Fengtai, Beijing, 100071, China.

出版信息

Adv Exp Med Biol. 2016;918:377-391. doi: 10.1007/978-94-024-0890-4_14.

DOI:10.1007/978-94-024-0890-4_14

PMID:27722871

Abstract

Yersinia pestis is a typical zoonotic bacterial pathogen. The following reasons make this pathogen a model for studying zoonotic pathogens: (1) Its unique lifestyle makes Y. pestis an ideal model for studying host-vector-environment-pathogen interactions; (2) population diversity characters in Y. pestis render it a model species for studying monomorphic bacterial evolution; (3) the pathogenic features of bacteria provide us with good opportunities to study human immune responses; (4) typical animal and vector models of Y. pestis infection create opportunities for experimental studies on pathogenesis and evolution; and (5) repeated pandemics and local outbreaks provide us with clues about the infectious disease outbreaks that have occurred in human history.

摘要

鼠疫耶尔森菌是一种典型的人畜共患细菌病原体。以下原因使这种病原体成为研究人畜共患病原体的模型：（1）其独特的生活方式使鼠疫耶尔森菌成为研究宿主-媒介-环境-病原体相互作用的理想模型；（2）鼠疫耶尔森菌的种群多样性特征使其成为研究单形细菌进化的模型物种；（3）该细菌的致病特征为我们研究人类免疫反应提供了良好机会；（4）鼠疫耶尔森菌感染的典型动物和媒介模型为发病机制和进化的实验研究创造了机会；（5）反复的大流行和局部暴发为我们提供了有关人类历史上发生的传染病暴发的线索。