Buchholz Frank, Hauber Joachim
Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Am Tatzberg 47/49, D-01307 Dresden, Germany.
Heinrich Pette Institute - Leibniz Institute for Experimental Virology, Martinistrasse 52, D-20251 Hamburg, Germany; German Center for Infection Research (DZIF), Partner Site Hamburg, Germany.
Curr Opin Virol. 2016 Oct;20:85-91. doi: 10.1016/j.coviro.2016.09.012. Epub 2016 Oct 7.
Chronic viral infections are often incurable because current antiviral strategies do not target chromosomally integrated or non-replicating episomal viral genomes. The rapid development of technologies for genome editing may possibly soon allow for therapeutic targeting of viral genomes and, hence, for development of curative strategies for persistent viral infection. However, detailed investigation of different antiviral genome editing approaches recently revealed various undesired effects. In particular, the problem of frequent and swift development of resistant viruses has to be thoroughly analysed before genome editing approaches become an established option for antiviral treatment.
慢性病毒感染往往无法治愈，因为目前的抗病毒策略并不针对染色体整合的或非复制型游离病毒基因组。基因组编辑技术的快速发展可能很快会使针对病毒基因组的治疗成为可能，从而为持续性病毒感染开发出治愈策略。然而，最近对不同抗病毒基因组编辑方法的详细研究揭示了各种不良影响。特别是，在基因组编辑方法成为抗病毒治疗的既定选择之前，必须对耐药病毒频繁且迅速出现的问题进行全面分析。
