米索硝唑代谢的某些方面。
Some aspects of the metabolism of misonidazole.
作者信息
Flockhart I R, Malcolm S L, Marten T R, Parkins C S, Ruane R J, Troup D
出版信息
Br J Cancer Suppl. 1978 Jun;3:264-7.
Abstract
The metabolism of the 2-nitroimidazole hypoxic cell radiosensitizer, misonidazole, has been studied in patients receiving radiotherapy. Results are presented which show that the compound reaches adequate levels in tumour tissue and that, in animal systems, reduction products of the nitro group may also be present. Ah h.p.l.c method is described which has been used to quantify unchanged misonidazole and its nitroimidazole metabolites.
摘要
在接受放射治疗的患者中，对2-硝基咪唑类乏氧细胞放射增敏剂米索硝唑的代谢情况进行了研究。研究结果表明，该化合物在肿瘤组织中能达到足够的浓度，并且在动物实验体系中，硝基的还原产物也可能存在。本文描述了一种高效液相色谱法，该方法已用于定量未变化的米索硝唑及其硝基咪唑代谢产物。
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本文引用的文献
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Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.放射增敏剂Ro-07-0582在人体中的血清浓度测量：一些初步结果。
Br J Cancer. 1975 Jun;31(6):679-83. doi: 10.1038/bjc.1975.115.
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Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
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