米索硝唑的临床研究。
Clinical studies with misonidazole.
作者信息
Wiltshire C R, Workman P, Watson J V, Bleehen N M
出版信息
Br J Cancer Suppl. 1978 Jun;3:286-9.
Abstract
The preliminary details of a randomized clinical trial of misonidazole for the radiotherapy of Grades 3 and 4 cerebral astrocytoma are described. Plasma concentrations of misonidazole and its O-demethylated metabolite, determined by high-pressure liquid chromatography analysis, are reported for 8 patients with astrocytoma, 1 with carcinoma of the bronchus and 1 with carcinoma of the breast. In the latter case, tumour concentrations are also presented.
摘要
本文描述了米索硝唑用于3级和4级脑星形细胞瘤放射治疗的一项随机临床试验的初步细节。通过高压液相色谱分析测定了8例星形细胞瘤患者、1例支气管癌患者和1例乳腺癌患者的米索硝唑及其O-去甲基代谢物的血浆浓度。对于后者，还给出了肿瘤浓度。
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引用本文的文献
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本文引用的文献
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2
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Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.放射增敏剂Ro-07-0582在人体中的血清浓度测量：一些初步结果。
Br J Cancer. 1975 Jun;31(6):679-83. doi: 10.1038/bjc.1975.115.
4
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.大剂量甲硝唑的1期研究：一种低氧细胞特异性的体内外放射增敏剂。
Radiology. 1975 Oct;117(1):129-33. doi: 10.1148/117.1.129.
5
Radiosensitizers of hypoxic cells in solid tumors.实体瘤中乏氧细胞的放射增敏剂
Cancer Treat Rev. 1976 Dec;3(4):227-56. doi: 10.1016/s0305-7372(76)80012-6.
6
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
7
Clinical testing of the radiosensitiser Ro-07-0582. III. Response of tumours.放射增敏剂Ro-07-0582的临床试验。III. 肿瘤反应
Clin Radiol. 1976 Apr;27(2):167-74. doi: 10.1016/s0009-9260(76)80139-0.
8
Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations.放射增敏剂Ro-07-0582的临床试验。I. 剂量耐受性、血清和肿瘤浓度。
Clin Radiol. 1976 Apr;27(2):151-7. doi: 10.1016/s0009-9260(76)80137-7.
9
Radiation and high-dose metronidazole in supratentorial glioblastomas.幕上胶质母细胞瘤中的放疗与大剂量甲硝唑
N Engl J Med. 1976 Jun 17;294(25):1364-7. doi: 10.1056/NEJM197606172942503.
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