阿司匹林脱敏在阿司匹林诱发的呼吸道疾病（AERD）患者中的作用。
The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD).
作者信息
Spies Jonas Willian, Valera Fabiana Cardoso Pereira, Cordeiro Daniel Loiola, de Mendonça Taís Nociti, Leite Marcelo Gonçalves Junqueira, Tamashiro Edwin, Arruda Luiza Karla, Anselmo-Lima Wilma Terezinha
机构信息
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
出版信息
Braz J Otorhinolaryngol. 2016 May-Jun;82(3):263-8. doi: 10.1016/j.bjorl.2015.04.010. Epub 2015 Sep 21.
INTRODUCTION
Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options.
OBJECTIVE
To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD.
METHODS
Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized.
RESULTS
Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up.
CONCLUSION
Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.
引言
阿司匹林诱发的呼吸道疾病（AERD）由一组典型的四联征组成：中度/重度哮喘、慢性鼻窦炎、鼻息肉以及对阿司匹林或其他非甾体抗炎药不耐受。药物治疗、手术治疗和脱敏治疗是可供选择的治疗方法。
目的
评估阿司匹林脱敏治疗对AERD患者的疗效和耐受性。
方法
对接受手术治疗且已脱敏的AERD患者进行定期症状评估和内镜检查。
结果
17例患者接受了脱敏治疗。8例患者完成了脱敏治疗，并接受了至少为期一年（平均3.1年）的随访。这些患者的所有症状均有所改善。此外，这些患者均无需再次进行手术评估，药物治疗和手术费用也有所降低。8例患者未完成脱敏治疗，主要原因是对治疗过程不耐受以及哮喘控制不佳，另有1例患者失访。
结论
对于耐受性良好的AERD患者，若其临床/手术反应不佳，阿司匹林脱敏治疗有效。
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