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TAS-102给药后药物性肺炎

Drug-induced Pneumonitis Following the Administration of TAS-102.

作者信息

Hasegawa Yoshikazu, Ota Takayo, Tsukuda Hiroshi, Suzumura Tomohiro, Fukuoka Masahiro

机构信息

Department of Medical Oncology, Izumi Municipal Hospital, Japan.

出版信息

Intern Med. 2016;55(19):2855-2859. doi: 10.2169/internalmedicine.55.6629. Epub 2016 Oct 1.

DOI:10.2169/internalmedicine.55.6629
PMID:27725548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5088549/
Abstract

A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities. The drug lymphocyte stimulation test for TAS-102 was strongly positive and serum β-D glucan level was elevated. The clinical course was compatible with TAS-102-induced pneumonitis combined with pneumocystis pneumonia (PCP). We herein report a rare case of drug-induced pneumonitis in a patient receiving TAS-102 in combination with PCP.

摘要

一名59岁女性，被诊断为晚期直肠癌，在接受TAS - 102的第2个周期后出现低热和劳力性呼吸困难。TAS - 102在转移性结直肠癌患者中具有良好的疗效。CT扫描显示双侧磨玻璃影呈马赛克样改变。TAS - 102的药物淋巴细胞刺激试验呈强阳性，血清β - D葡聚糖水平升高。临床过程符合TAS - 102诱导的肺炎合并肺孢子菌肺炎（PCP）。我们在此报告1例接受TAS - 102联合PCP治疗的患者发生药物性肺炎的罕见病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/e3e6dfe73d7f/1349-7235-55-2855-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/d87a27a11dee/1349-7235-55-2855-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/bac98a99d0b3/1349-7235-55-2855-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/45ca9cc06270/1349-7235-55-2855-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/e3e6dfe73d7f/1349-7235-55-2855-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/d87a27a11dee/1349-7235-55-2855-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/bac98a99d0b3/1349-7235-55-2855-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/45ca9cc06270/1349-7235-55-2855-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cdc/5088549/e3e6dfe73d7f/1349-7235-55-2855-g004.jpg

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本文引用的文献

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Randomized trial of TAS-102 for refractory metastatic colorectal cancer.TAS-102 治疗难治性转移性结直肠癌的随机试验。
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Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.在小鼠模型中，重复口服给药TAS-102可使三氟尿苷大量掺入DNA并具有持续的抗肿瘤活性。
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药物性肺损伤诊断与治疗的共识声明。
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