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高传能线密度辐射与增敏剂的联合使用。

A combination of sensitizers with high LET radiations.

作者信息

Raju M R, Amols H I, Carpenter S G

出版信息

Br J Cancer Suppl. 1978 Jun;3:189-93.

PMID:277224
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149392/
Abstract

Preliminary measurements of OER for pion beams in combination with a concentration of Misonidazole (0.4 mM) that is realistic in radiotherapeutic application are reported. These results indicate that 0.4 mM of misonidazole is as effective in reducing OER for negative pions as for X-rays. The application of high LET radiations in combination with hypoxic cell sensitizers is discussed.

摘要

报告了在放射治疗应用中与实际浓度的米索硝唑(0.4 mM)相结合的π介子束的氧增强比(OER)的初步测量结果。这些结果表明,0.4 mM的米索硝唑在降低负π介子的OER方面与X射线一样有效。讨论了高传能线密度(LET)辐射与乏氧细胞增敏剂联合应用的情况。

相似文献

1
A combination of sensitizers with high LET radiations.高传能线密度辐射与增敏剂的联合使用。
Br J Cancer Suppl. 1978 Jun;3:189-93.
2
Hypoxic cell sensitizers and heavy charged-particle radiations.缺氧细胞增敏剂与重带电粒子辐射
Br J Cancer Suppl. 1978 Jun;3:184-8.
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Interaction between electron-affinic sensitizers.亲电子敏化剂之间的相互作用。
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The nitroimidazoles as radiosensitizers and cytotoxic agents.作为放射增敏剂和细胞毒剂的硝基咪唑类药物。
Br J Cancer Suppl. 1978 Jun;3:120-3.
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Cytotoxic and radiosensitizing effects of hypoxic cell sensitizers on EMT6 mouse mammary tumour cells in vivo and in vitro.乏氧细胞增敏剂对EMT6小鼠乳腺肿瘤细胞的体内外细胞毒性及放射增敏作用
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Effects of oxygen and misonidazole on cell transformation and cell killing in C3H 10T1/2 cells by X rays in vitro.氧气和米索硝唑对X射线体外诱导C3H 10T1/2细胞转化及细胞杀伤的影响。
Radiat Res. 1984 Oct;100(1):96-103.
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Sensitizing and toxicity properties of misonidazole and its derivatives.米索硝唑及其衍生物的致敏性和毒性特性。
Br J Cancer Suppl. 1978 Jun;3:115-9.
8
The effect of misonidazole as a hypoxic radiosensitizer at low dose.低剂量米索硝唑作为低氧放射增敏剂的作用。
Radiat Res. 1984 Nov;100(2):340-7.
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Misonidazole and MTDQ in combination: cytotoxic and radiosensitizing properties in hypoxic mammalian cells.米索硝唑与MTDQ联合应用:对缺氧哺乳动物细胞的细胞毒性和放射增敏特性
Br J Cancer. 1979 May;39(5):510-5. doi: 10.1038/bjc.1979.94.
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Hypoxic sensitizers: radiobiological studies at the cellular level.缺氧敏化剂:细胞水平的放射生物学研究
Radiology. 1975 Nov;117(2):453-7. doi: 10.1148/117.2.453.

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本文引用的文献

1
RBE and OER variations of mixtures of plutonium alpha particles and X-rays for damage to human kidney cells (T-1).
Radiat Res. 1974 Dec;60(3):473-81.
2
The biophysical properties of 3.9-GeV nitrogen ions. IV. OER and RBE determinations using cultured mammalian cells.3.9吉电子伏特氮离子的生物物理特性。IV. 使用培养的哺乳动物细胞进行氧增强比(OER)和相对生物效应(RBE)测定
Radiat Res. 1973 Sep;55(3):431-6.
3
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验:多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
4
The response of a transplantable tumor to fractionated irradiation. III. Fast neutrons plus the radiosensitizer Ro-07-0582.可移植肿瘤对分次照射的反应。III. 快中子加放射增敏剂Ro-07-0582
Radiat Res. 1977 May;70(2):425-32.
5
Radiobiological properties of high-energy cyclotron-produced neutrons used for radiotherapy.
Radiology. 1975 Oct;117(1):173-8. doi: 10.1148/117.1.173.
6
The use of hypoxic cell radiosensitizers with mixed X and alpha radiations.混合X射线和α射线的低氧细胞放射增敏剂的应用。
Radiat Res. 1977 Jul;71(1):233-9.