César J M, Fernández I, Navarro J L
Sangre (Barc). 1989 Aug;34(4):300-2.
The amount and distribution of phospholipids (PLs) were studied in erythrocytes, plasma and platelets of one patient with hereditary spherocytosis (HS). Phosphatidylethanolamine (PE) was always decreased. Total PLs amount was remarkably reduced in erythrocytes but normal in platelets. Since platelets do not contain those proteins which have been implicated in the red cell abnormalities of patients with HS, our findings reinforce the theory that a defective protein-lipid interaction causes the abnormal lipid loss in the erythrocytes of these patients.
对一名遗传性球形红细胞增多症（HS）患者的红细胞、血浆和血小板中的磷脂（PLs）含量及分布进行了研究。磷脂酰乙醇胺（PE）含量始终降低。红细胞中的总PLs含量显著降低，但血小板中的总PLs含量正常。由于血小板不含有那些与HS患者红细胞异常有关的蛋白质，我们的研究结果强化了这样一种理论，即蛋白质-脂质相互作用缺陷导致这些患者红细胞中脂质异常丢失。
