Saitoh Masakazu, Dos Santos Marcelo Rodrigues, Anker Markus, Anker Stefan D, von Haehling Stephan, Springer Jochen
Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen, Germany.
Innovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen, Germany; Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.
Int J Cardiol. 2016 Dec 15;225:200-205. doi: 10.1016/j.ijcard.2016.09.127. Epub 2016 Oct 1.
Neuromuscular electrical stimulation (NMES) seems to be safe and beneficial in improvement in functional capacity, muscle strength, and quality of life when compared with conventional aerobic exercise, while the change in muscle fiber composition and muscle size was conflicting in patients with heart failure (HF). Moreover, NMES studies seem to have beneficial effects on pro-inflammatory cytokine, oxidative enzyme activity, and protein anabolic and catabolic metabolism that are the key molecular mechanism of muscle wasting in patients with HF. We review specific issues related to the effects of NMES on muscle wasting in patients with HF, whether NMES seems to be an alternative exercise modality preventing or improving in muscle wasting for HF patients who are unable or unwilling to engage in conventional exercise training; however no established strategies currently exist to focus on the patients with HF accompanied by muscle wasting.
与传统有氧运动相比，神经肌肉电刺激（NMES）在改善心力衰竭（HF）患者的功能能力、肌肉力量和生活质量方面似乎是安全且有益的，然而，HF患者的肌肉纤维组成和肌肉大小变化存在矛盾。此外，NMES研究似乎对促炎细胞因子、氧化酶活性以及蛋白质合成代谢和分解代谢有有益影响，这些是HF患者肌肉萎缩的关键分子机制。我们回顾了与NMES对HF患者肌肉萎缩影响相关的具体问题，即NMES是否似乎是一种替代运动方式，可预防或改善无法或不愿进行传统运动训练的HF患者的肌肉萎缩；然而，目前尚无既定策略来关注伴有肌肉萎缩的HF患者。
