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体外受精程序中的附加物——炒作还是希望?

Add-ons in IVF programme - Hype or Hope?

作者信息

Datta A K, Campbell S, Deval B, Nargund G

机构信息

CREATE Fertility, 150 Cheapside, St Pauls, London EC2V 6ET, United Kingdom.

出版信息

Facts Views Vis Obgyn. 2015 Dec 28;7(4):241-250.

PMID:27729969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5058413/
Abstract

A series of new technologies and adjuvant therapies have been advocated in order to improve the success of IVF treatment. Dehydro-epiandrostenedione, growth hormones, Coenzyme Q 10, calcium ionosphores, immune therapy, heparin, low-dose aspirin, and vasodilators are among commonly prescribed pharmacological adjuvants. New technologies that are proposed to improve IVF outcomes include advanced sperm selection procedures, time- lapse embryo monitoring, preimplantation genetic screening, assisted hatching endometrial injury or embryo-glue. This review looked into current evidence to justify the use of these co-interventions and whether some of them can still be offered while awaiting more robust evidence to con rm or refute their role.

摘要

为了提高体外受精(IVF)治疗的成功率,人们提倡一系列新技术和辅助疗法。脱氢表雄酮、生长激素、辅酶Q10、钙离子载体、免疫疗法、肝素、低剂量阿司匹林和血管扩张剂是常用的药物辅助剂。旨在改善IVF结果的新技术包括先进的精子筛选程序、延时胚胎监测、植入前基因筛查、辅助孵化、子宫内膜损伤或胚胎胶。本综述研究了当前的证据,以证明这些联合干预措施的使用合理性,以及在等待更有力的证据来证实或反驳它们的作用时,其中一些措施是否仍可提供。

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引用本文的文献

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Reprod Sci. 2023 Nov;30(11):3253-3260. doi: 10.1007/s43032-023-01233-9. Epub 2023 May 30.
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Revisiting selected ethical aspects of current clinical in vitro fertilization (IVF) practice.重新审视当前临床体外受精 (IVF) 实践中的部分伦理问题。
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Fertility interventions 'add-ons' in clinical ART practice: Ethical, Moral and Commercial Considerations.辅助生殖技术临床实践中的生育干预“附加项”:伦理、道德与商业考量
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本文引用的文献

1
A double-blind randomised controlled trial on the effect of dehydroepiandrosterone on ovarian reserve markers, ovarian response and number of oocytes in anticipated normal ovarian responders.脱氢表雄酮对预期正常卵巢反应者的卵巢储备标志物、卵巢反应和卵母细胞数量的影响的双盲随机对照试验。
BJOG. 2016 Jun;123(7):1097-105. doi: 10.1111/1471-0528.13808. Epub 2015 Dec 10.
2
Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction.雄激素(脱氢表雄酮或睾酮)用于接受辅助生殖的女性。
Cochrane Database Syst Rev. 2015 Nov 26;2015(11):CD009749. doi: 10.1002/14651858.CD009749.pub2.
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A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.对接受体外受精或卵胞浆内单精子注射的卵巢储备功能减退女性补充脱氢表雄酮的一项荟萃分析。
Int J Gynaecol Obstet. 2015 Dec;131(3):240-5. doi: 10.1016/j.ijgo.2015.06.028. Epub 2015 Sep 6.
4
Which is the best IVF/ICSI protocol to be used in poor responders receiving growth hormone as an adjuvant treatment? A prospective randomized trial.对于接受生长激素作为辅助治疗的低反应者,哪种体外受精/卵胞浆内单精子注射方案最佳?一项前瞻性随机试验。
Gynecol Endocrinol. 2016;32(2):116-9. doi: 10.3109/09513590.2015.1092136. Epub 2015 Sep 29.
5
Comprehensive chromosome screening improves embryo selection: a meta-analysis.综合染色体筛查改善胚胎选择:一项荟萃分析。
Fertil Steril. 2015 Dec;104(6):1503-12. doi: 10.1016/j.fertnstert.2015.08.038. Epub 2015 Sep 16.
6
Can calcium ionophore "use" in patients with diminished ovarian reserve increase fertilization and pregnancy rates? A randomized, controlled study.钙离子载体“用于”卵巢储备功能减退患者能否提高受精率和妊娠率?一项随机对照研究。
Fertil Steril. 2015 Nov;104(5):1168-74. doi: 10.1016/j.fertnstert.2015.07.1163. Epub 2015 Sep 3.
7
Low-dose growth hormone supplementation increases clinical pregnancy rate in poor responders undergoing in vitro fertilisation.低剂量生长激素补充剂可提高接受体外受精的反应不良者的临床妊娠率。
Gynecol Endocrinol. 2015 Jul;31(7):565-8. doi: 10.3109/09513590.2015.1025378. Epub 2015 Jul 21.
8
Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.辅酶Q10可恢复生殖衰老过程中卵母细胞的线粒体功能和生育能力。
Aging Cell. 2015 Oct;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26.
9
Artificial oocyte activation to improve reproductive outcomes in women with previous fertilization failure: a systematic review and meta-analysis of RCTs.人工卵母细胞激活以改善既往受精失败女性的生殖结局:随机对照试验的系统评价和荟萃分析。
Hum Reprod. 2015 Aug;30(8):1831-41. doi: 10.1093/humrep/dev136. Epub 2015 Jun 16.
10
Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials.低分子肝素联合阿司匹林与单独应用阿司匹林治疗遗传性血栓形成倾向孕妇以提高活产率:随机对照试验的荟萃分析。
Arch Gynecol Obstet. 2016 Jan;293(1):81-86. doi: 10.1007/s00404-015-3782-2. Epub 2015 Jun 10.