Orywal Karolina, Jelski Wojciech, Szmitkowski Maciej
Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej.
Pol Merkur Lekarski. 2008 Jun;24(144):565-7.
Chronic alcohol consumption is a risk factor for many cancers, e.g. upper digestive tract, liver, pancreas, colorectum and breast. The main role in carcinogenesis plays toxic and carcinogenic acetaldehyde. Formation and degradation of acetaldehyde in the body is modified by activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). They are polymorphic enzymes localized in different organs and catalyzing many others biochemical reactions.
长期饮酒是许多癌症的危险因素，如消化道上段、肝脏、胰腺、结肠直肠和乳腺的癌症。致癌过程中起主要作用的是有毒且致癌的乙醛。体内乙醛的形成和降解受乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）活性的影响。它们是多态性酶，存在于不同器官中，还催化许多其他生化反应。
