Gauri L A, Thaned Ashok, Fatima Q, Yadav H, Singh A, Jaipal H P, Chaudhary A
Department of Medicine and Pathology, SP Medical College, Bikaner, Rajasthan.
J Assoc Physicians India. 2016 Mar;64(3):22-25.
To find out clinical and laboratory profile of patients of chikungunya outbreak in 2006 in Bikaner (North-West Rajasthan) and follow up of chikungunya patients for 5 years.
Study was conducted among 50 chikungunya patients. For this study the inclusion criteria was clinical presentation consistent with chikungunya virus infection (e.g. abrupt onset of fever and/or polyarthralgia) and laboratory confirmation of chikungunya virus infection by IgM-capture ELISA. All patients were subjected for thorough clinical and general physical examination, investigations like CBC, ESR, CRP, rheumatoid factor, ECG, LFT, RFT, anti-CCP antibody were done in all patients and their follow up was done for 5 years.
Among the 50 patients of chikungunya arthritis 34 (68%) patients developed persistent arthritis. Among the patients with persistent arthritis 70.58% were shown positive for anti-ccp antibody. CRP (95.24%) and ESR level were raised (68%) in patient with persistent arthralgia. Level of CRP and ESR was proportionally related to number of partially recovered joints, higher the CRP positivity and raised ESR levels severe were the persistent arthralgias.
Our study shows that chikungunya patients who had persistent arthralgia on 5 year follow up mimicked rheumatological disorder like rheumatoid arthritis in 70.58%. Therefore DMARD can be effective.
了解2006年比卡内尔（拉贾斯坦邦西北部）基孔肯雅热疫情患者的临床和实验室特征，并对基孔肯雅热患者进行5年随访。
对50例基孔肯雅热患者进行研究。本研究的纳入标准为临床表现符合基孔肯雅病毒感染（如突发发热和/或多关节痛），并通过IgM捕获ELISA进行基孔肯雅病毒感染的实验室确诊。所有患者均接受全面的临床和全身体格检查，对所有患者进行血常规、血沉、C反应蛋白、类风湿因子、心电图、肝功能、肾功能、抗环瓜氨酸肽抗体等检查，并对其进行5年随访。
在50例基孔肯雅热关节炎患者中，34例（68%）出现持续性关节炎。在持续性关节炎患者中，70.58%的抗环瓜氨酸肽抗体呈阳性。持续性关节痛患者的C反应蛋白（95.24%）和血沉水平升高（68%）。C反应蛋白和血沉水平与部分恢复关节的数量成比例相关，C反应蛋白阳性率越高、血沉水平升高越明显，持续性关节痛越严重。
我们的研究表明，在5年随访中出现持续性关节痛的基孔肯雅热患者中有70.58%类似类风湿关节炎等风湿性疾病。因此，改善病情抗风湿药可能有效。
