静脉注射全氟碳化合物及吸氧对仓鼠急性减压病的影响。

Effects of intravenous perfluorocarbon and oxygen breathing on acute decompression sickness in the hamster.

作者信息

Lynch P R, Krasner L J, Vinciquerra T, Shaffer T H

机构信息

Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

出版信息

Undersea Biomed Res. 1989 Jul;16(4):275-81.

PMID:2773159

Abstract

Anesthetized female hamsters (Mesocricetus auratus) were divided into 3 experimental groups with 16 animals in each group. After control arterial blood pressure and ECG recordings, the animals were placed in a hyperbaric chamber for 30 min at 7 ATA and then decompressed directly to the surface at a rate of 60 fsw/min. After their removal from the chamber, animals were either not treated (group 1); given i.v. saline while breathing 100% oxygen (group 2), or given i.v. oxypherolperfluorochemical (Fluosol-43) perfusion emulsion while breathing 100% oxygen (group 3). Thirty minutes after decompression, all but one of group 1 had died (a 6% survival rate). Group 2 had a 62% survival rate and group 3 had a 94% survival rate. Perfluorochemicals were observed to reduce the number of bubbles formed, enhance bubble disappearance, and reduce dysrhythmias.

摘要

将麻醉后的雌性仓鼠（金黄地鼠）分为3个实验组，每组16只动物。记录对照动脉血压和心电图后，将动物置于7个绝对大气压的高压舱中30分钟，然后以每分钟60英尺海水深度的速度直接减压至水面。从舱中取出后，一组动物不做处理（第1组）；一组在呼吸100%氧气的同时静脉注射生理盐水（第2组），另一组在呼吸100%氧气的同时静脉注射全氟化学物质（氟碳乳液-43）灌注乳剂（第3组）。减压30分钟后，第1组除1只外全部死亡（存活率6%）。第2组存活率为62%，第3组存活率为94%。观察到全氟化学物质可减少气泡形成数量，促进气泡消失，并减少心律失常。