Vanparijs O, Hermans L, van der Flaes L, Marsboom R
Janssen Pharmaceutica, Beerse, Belgium.
Vet Parasitol. 1989 Jul 15;32(2-3):109-17. doi: 10.1016/0304-4017(89)90111-8.
The efficacy of diclazuril against intestinal and hepatic coccidiosis was studied in artificially infected rabbits. Prophylaxis against intestinal coccidiosis was evaluated using a mixed infection of Eimeria intestinalis, Eimeria magna and Eimeria perforans. Continuous medication in the feed at 1 p.p.m. was 100% effective in reducing oocyst output and faecal scores, and weight gain and feed efficiency were normal. Hepatic coccidiosis induced by Eimeria stiedai was prevented at 0.5 and 1 p.p.m. as shown by negative oocyst counts, normal liver weight, absence of liver lesions, and normal body-weight gain and feed efficiency. Medication at 1 p.p.m. for 7 consecutive days during the prepatent phase of hepatic coccidiosis resulted in large reductions in oocyst counts and lesion scores with a normal liver weight and growth performance. Diclazuril at 1 p.p.m. in the feed prevented both intestinal and hepatic coccidiosis in rabbits and can be advocated for safe mass medication.
在人工感染的家兔中研究了地克珠利对肠道和肝脏球虫病的疗效。使用肠艾美耳球虫、大型艾美耳球虫和穿孔艾美耳球虫的混合感染来评估对肠道球虫病的预防效果。饲料中以百万分之一的浓度持续给药，在减少卵囊排出量和粪便评分方面有100%的效果，并且体重增加和饲料效率正常。由斯氏艾美耳球虫引起的肝脏球虫病在百万分之0.5和百万分之一的浓度下得到预防，表现为卵囊计数为阴性、肝脏重量正常、无肝脏病变以及体重增加和饲料效率正常。在肝脏球虫病的潜隐期连续7天以百万分之一的浓度给药，可使卵囊计数和病变评分大幅降低，同时肝脏重量和生长性能正常。饲料中百万分之一浓度的地克珠利可预防家兔的肠道和肝脏球虫病，可推荐用于安全的大规模给药。
