Peeters J E, Geeroms R
Vet Parasitol. 1986 Nov;22(1-2):21-35. doi: 10.1016/0304-4017(86)90004-x.
The anticoccidial effect of toltrazuril (Bay Vi 9142) against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally-infected rabbits. Continuous administration of 10-15 p.p.m. of the drug in the drinking water was highly effective in reducing oocyst output of all five species and in preventing clinical signs and macroscopic lesions. Sporulation of excreted oocysts was not affected. After 5 weeks of medication, no negative influence was noted on zootechnic performance of growing healthy rabbits. Medication of rabbits with 25 p.p.m. only during schizogony or gamogony (2 days of treatment, repeated after 5 days) quickly reduced clinical signs and oocyst output. When administered during late schizogony or gamogony, toltrazuril allowed development of immunity against reinfection with homologous species.
在实验感染的兔子中测试了托曲珠利（Bay Vi 9142）对黄艾美耳球虫、肠艾美耳球虫、大型艾美耳球虫、穿孔艾美耳球虫和斯氏艾美耳球虫的抗球虫作用。在饮用水中持续给予10 - 15 ppm的该药物，在减少所有五种球虫的卵囊排出量以及预防临床症状和宏观病变方面非常有效。排出的卵囊的孢子化未受影响。用药5周后，未观察到对生长健康兔子的饲养性能有负面影响。仅在裂殖生殖期或配子生殖期（治疗2天，5天后重复）用25 ppm的药物给兔子用药，可迅速减轻临床症状和卵囊排出量。当在裂殖生殖后期或配子生殖期给药时，托曲珠利可使兔子产生针对同源球虫再感染的免疫力。
