Kling Jessica C, Blumenthal Antje
The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia; and
Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
J Leukoc Biol. 2017 Apr;101(4):827-840. doi: 10.1189/jlb.1MR0616-272R. Epub 2016 Oct 12.
Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate-like lymphocytes.
固有淋巴细胞（ILCs）和固有样淋巴细胞在感染、癌症及自身免疫背景下的免疫反应中发挥着重要作用。驱动这些细胞类型分化和功能的相关因素仍有待明确界定。有几种细胞信号通路参与胚胎发育过程，且在成体组织中仍持续发挥作用。特别是，WNT、NOTCH和Hedgehog信号通路正逐渐成为造血细胞发育和分化的调节因子。本综述讨论了WNT、NOTCH和Hedgehog信号在固有淋巴细胞和固有样淋巴细胞的分化及功能方面目前已知的作用。
