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Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

作者信息

Varney M E, Choi K, Bolanos L, Christie S, Fang J, Grimes H L, Maciejewski J P, Inoue J-I, Starczynowski D T

机构信息

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

出版信息

Leukemia. 2017 Feb;31(2):491-495. doi: 10.1038/leu.2016.276. Epub 2016 Oct 3.

DOI:10.1038/leu.2016.276
PMID:27733775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5729588/
Abstract
摘要

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本文引用的文献

1
Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.逆转录病毒插入诱变确定了5号染色体长臂缺失（del(5q)）相关基因CXXC5、TIFAB和ETF1，以及Wnt信号通路，它们是del(5q)骨髓肿瘤的潜在靶点。
Haematologica. 2016 Jun;101(6):e232-6. doi: 10.3324/haematol.2015.139527. Epub 2016 Mar 4.
2
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.Tifab（一种5号染色体长臂缺失相关的骨髓增生异常综合征基因）的缺失通过解除Toll样受体-TRAF6信号通路的抑制来改变造血作用。
J Exp Med. 2015 Oct 19;212(11):1967-85. doi: 10.1084/jem.20141898. Epub 2015 Oct 12.
3
Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.伴有5号染色体长臂缺失的髓系恶性肿瘤对染色体内部的核因子κB基因网络产生依赖。
Cell Rep. 2014 Sep 11;8(5):1328-38. doi: 10.1016/j.celrep.2014.07.062. Epub 2014 Sep 4.
4
MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice.微小RNA-146a在小鼠中作为造血干细胞质量和寿命的守护者。
Elife. 2013 May 21;2:e00537. doi: 10.7554/eLife.00537.
5
NetWalker: a contextual network analysis tool for functional genomics.NetWalker：一种用于功能基因组学的语境网络分析工具。
BMC Genomics. 2012 Jun 25;13:282. doi: 10.1186/1471-2164-13-282.
6
Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited.重新探讨 5q 髓系恶性肿瘤的解剖学、临床和基因组相关性。
J Clin Oncol. 2012 Apr 20;30(12):1343-9. doi: 10.1200/JCO.2011.36.1824. Epub 2012 Feb 27.
7
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies.miR-146a 缺陷型小鼠中 NF-κB 的失调导致髓系恶性肿瘤的发生。
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9184-9. doi: 10.1073/pnas.1105398108. Epub 2011 May 16.
8
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.miR-146a 是小鼠自身免疫、骨髓增生和癌症的重要制动因素。
J Exp Med. 2011 Jun 6;208(6):1189-201. doi: 10.1084/jem.20101823. Epub 2011 May 9.
9
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.骨髓增生异常综合征造血干细胞中失调的基因表达途径。
Leukemia. 2010 Apr;24(4):756-64. doi: 10.1038/leu.2010.31. Epub 2010 Mar 11.
10
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.鉴定 miR-145 和 miR-146a 作为 5q-综合征表型的介质。
Nat Med. 2010 Jan;16(1):49-58. doi: 10.1038/nm.2054. Epub 2009 Nov 8.