Trubitsyna N V, Mikheev A M, Berezin V A, Efimov O E, Privalova L I
Vopr Med Khim. 1989 May-Jun;35(3):133-6.
Prealbumin, albumin, alpha 1-antitrypsin, alpha 1-antichymotrypsin, ceruloplasmin, haptoglobin, transferrin, IgG, IgM and IgA were studied in blood serum of healthy donors and of patients with chronic alcoholism by means of cross immuno-electrophoresis and immunodiffusion. Only content of alpha 1-antitrypsin was distinctly altered in blood serum of the patients with alcoholism as compared with normal state, while individual variations in content of the proteins studied were considerably higher in blood serum of the patients. At the same time, distinct dissimilarity of the patterns studied was found between healthy donors and patients with chronic alcoholism when concentration ratios of some positively and negatively charged acute phase proteins were calculated (alpha 1-antitrypsin/albumin, haptoglobin/albumin, haptoglobin/transferrin).
通过交叉免疫电泳和免疫扩散法，对健康献血者和慢性酒精中毒患者血清中的前白蛋白、白蛋白、α1-抗胰蛋白酶、α1-抗糜蛋白酶、铜蓝蛋白、触珠蛋白、转铁蛋白、IgG、IgM和IgA进行了研究。与正常状态相比，酒精中毒患者血清中仅α1-抗胰蛋白酶含量有明显改变，而患者血清中所研究蛋白质含量的个体差异则大得多。同时，计算某些正负电荷急性期蛋白的浓度比（α1-抗胰蛋白酶/白蛋白、触珠蛋白/白蛋白、触珠蛋白/转铁蛋白）时，发现健康献血者和慢性酒精中毒患者之间所研究的图谱存在明显差异。
