Shinagawa S, Saitoh M
Biol Res Pregnancy Perinatol. 1983;4(4):140-4.
Immunologic analyses of urinary proteins in patients with gestosis and related obstetrical conditions were performed and urinary protein patterns were compared with blood plasma protein patterns. Many kinds of proteins could be detected in urine of patients with gestosis beside albumin. Therefore, "proteinuria" should be chosen to characterise this state instead of the term "albuminuria". Generally speaking, when a total volume of protein contained in urine increases, its types or subfractions also increase in urine. Next to albumin, the most commonly detected proteins in urine of patients with gestosis were transferrin, IgG, inter-alpha-trypsin inhibitor, alpha 1-antitrypsin, IgA, alpha 2-HS-glycoprotein, alpha 1-acid glycoprotein, Gc-globulin, alpha 1-antichymotrypsin, hemopexin, ceruloplasmin, prealbumin, haptoglobin, anti-thrombin III, Cl-inactivator, IgM, and alpha 2-macroglobulin, in the descending order of their occurrence. Proteins that promptly became negative in urine of gestosis patients after delivery were inter-alpha-trypsin inhibitor, IgA, and ceruloplasmin. On the other hand, proteins most apt to persist in urine were albumin, alpha 2-HS-glycoprotein, and IgG. Generally speaking, lower molecular weight proteins were likely to persist in urine after delivery. Simultaneous determination of blood plasma and urinary proteins was performed for 18 kinds or subfractions of protein. A prognostic value of renal protein clearance was discussed.
对妊娠中毒症及相关产科疾病患者的尿蛋白进行了免疫学分析，并将尿蛋白模式与血浆蛋白模式进行了比较。除白蛋白外，妊娠中毒症患者的尿液中还能检测到多种蛋白质。因此，应选用“蛋白尿”来描述这种状态，而不是“白蛋白尿”这个术语。一般来说，当尿液中所含蛋白质的总量增加时，其类型或亚组分在尿液中也会增加。除白蛋白外，妊娠中毒症患者尿液中最常检测到的蛋白质依次为转铁蛋白、IgG、α-胰蛋白酶抑制剂、α1-抗胰蛋白酶、IgA、α2-HS-糖蛋白、α1-酸性糖蛋白、Gc球蛋白、α1-抗糜蛋白酶、血红素结合蛋白、铜蓝蛋白、前白蛋白、触珠蛋白、抗凝血酶III、C1灭活剂、IgM和α2-巨球蛋白。产后妊娠中毒症患者尿液中迅速转阴的蛋白质是α-胰蛋白酶抑制剂、IgA和铜蓝蛋白。另一方面，最容易在尿液中持续存在的蛋白质是白蛋白、α2-HS-糖蛋白和IgG。一般来说，分子量较低的蛋白质在产后更有可能持续存在于尿液中。对18种蛋白质或蛋白质亚组分同时进行了血浆和尿蛋白的测定。并讨论了肾蛋白清除率的预后价值。
