Chiriat'ev E A, Leonova O P, Byshevskiĭ A Sh
Vopr Med Khim. 1989 May-Jun;35(3):96-100.
Three peptides, inhibitors of fibrin self-assembly, were shown to be responsible for stable antipolymerization activity of blood plasma. Similarity of amino acid composition of these inhibitors might be considered as an indication of their origin from a common precursor by means of limited proteolysis. Inhibition of the self-assembly occurred due to interaction of the peptides with monomeric fibrin in the region of domain D, which was accompanied by loosening of electrostatic interactions between molecules of fibrin.
三种抑制纤维蛋白自组装的肽被证明是血浆稳定抗聚合活性的原因。这些抑制剂氨基酸组成的相似性可能被视为它们通过有限蛋白水解作用源自共同前体的一个迹象。自组装的抑制是由于这些肽与结构域D区域的单体纤维蛋白相互作用而发生的，这伴随着纤维蛋白分子间静电相互作用的减弱。
