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嗜酸性粒细胞增多综合征的胃肠道和肝脏受累情况

Gastrointestinal and Hepatic Involvement in Hypereosinophilic Syndrome.

作者信息

Inayat Faisal, Hurairah Abu

机构信息

Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York City, NY, USA.

Division of Gastroenterology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.

出版信息

Cureus. 2016 Aug 31;8(8):e760. doi: 10.7759/cureus.760.

DOI:10.7759/cureus.760
PMID:27733964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5045328/
Abstract

The objective of this investigation was to study the gastrointestinal and hepatic involvement in hypereosinophilic syndrome (HES). Gastrointestinal or hepatic involvement is estimated to affect up to one-third of patients with HES, although most of the clinical evidence has been derived from case reports. In literature, HES presenting with hepatitis and jaundice with subsequent development of colitis is a rare clinicopathologic entity. Given the clinical implications, physicians should include HES among differentials in these types of presentations.

摘要

本研究的目的是探讨高嗜酸性粒细胞综合征(HES)患者的胃肠道和肝脏受累情况。据估计,高达三分之一的HES患者会出现胃肠道或肝脏受累,尽管大多数临床证据来自病例报告。在文献中,HES伴有肝炎和黄疸并随后发展为结肠炎是一种罕见的临床病理实体。鉴于其临床意义,医生在这些类型的临床表现的鉴别诊断中应将HES纳入考虑范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/140d79a195ca/cureus-0008-000000000760-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/1720fe56d1e2/cureus-0008-000000000760-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/13da2b71a41c/cureus-0008-000000000760-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/57b795e4bd54/cureus-0008-000000000760-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/5b6d7a6c6158/cureus-0008-000000000760-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/0f84a52b3e94/cureus-0008-000000000760-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/140d79a195ca/cureus-0008-000000000760-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/1720fe56d1e2/cureus-0008-000000000760-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/13da2b71a41c/cureus-0008-000000000760-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/57b795e4bd54/cureus-0008-000000000760-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/5b6d7a6c6158/cureus-0008-000000000760-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/0f84a52b3e94/cureus-0008-000000000760-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6681/5045328/140d79a195ca/cureus-0008-000000000760-i06.jpg

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本文引用的文献

1
Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia.以肝炎和贲门失弛缓症为表现的特发性嗜酸性粒细胞增多综合征
Clin J Gastroenterol. 2016 Aug;9(4):238-42. doi: 10.1007/s12328-016-0661-8. Epub 2016 Jun 13.
2
A Possible Case of Hepatitis due to Hypereosinophilic Syndrome.一例可能由高嗜酸性粒细胞综合征引起的肝炎病例。
Intern Med. 2016;55(11):1453-8. doi: 10.2169/internalmedicine.55.5982. Epub 2016 Jun 1.
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Recurrent severe acute hepatitis caused by hypereosinophilic syndrome associated with elevated serum immunoglobulin G4 levels.
伴有皮肤受累的特发性高嗜酸性粒细胞综合征:32例病例的比较性综述
BMJ Case Rep. 2018 Dec 3;11(1):bcr2018227137. doi: 10.1136/bcr-2018-227137.
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Identification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity.鉴定出一个新的 PDGFRA 点突变 p.P6L,该突变可能成为伊马替尼在表现出遗传异质性的嗜酸性粒细胞增多症患者中的潜在分子靶标。
Cancer Biol Ther. 2019;20(4):402-407. doi: 10.1080/15384047.2018.1532558. Epub 2018 Oct 25.
由嗜酸性粒细胞增多综合征伴血清免疫球蛋白G4水平升高引起的复发性严重急性肝炎。
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