Tange Shuichi, Uchino Koji, Kakiwaki Hirotoshi, Suzuki Hirobumi, Yamamoto Shinzo, Ito Yukiko, Taniguchi Hiroyoshi, Shirai Harumi, Suzuki Takeshi, Onoyama Haruna, Nagaoka Sakae, Kumasaka Toshio, Yoshida Hideo
Department of Gastroenterology, Japanese Red Cross Medical Center, Japan.
Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, Japan.
Intern Med. 2022 May 15;61(10):1525-1529. doi: 10.2169/internalmedicine.8283-21. Epub 2021 Oct 19.
A 78-year-old woman presenting with severe acute liver failure was admitted to our hospital. On screening for the etiology of acute liver failure, it was diagnosed as being due to idiopathic hypereosinophilic syndrome (eosinophil count reported as 4766/μL; 33.8% of the white blood cells). Her medical history included marked eosinophilia, as observed six months prior to this admission. Corticosteroid therapy was initiated. During the clinical course, duodenal perforation occurred but was managed promptly by appropriate surgery. A liver biopsy, following the initiation of corticosteroid therapy, revealed degenerating hepatic cells with mild eosinophilic infiltration. With corticosteroid therapy, the liver function improved.
一名78岁患有严重急性肝衰竭的女性被收治入院。在筛查急性肝衰竭病因时，诊断为特发性嗜酸性粒细胞增多综合征（嗜酸性粒细胞计数报告为4766/μL，占白细胞的33.8%）。她的病史包括此次入院前六个月观察到的明显嗜酸性粒细胞增多。开始使用皮质类固醇治疗。在临床过程中，发生了十二指肠穿孔，但通过适当的手术及时进行了处理。皮质类固醇治疗开始后进行的肝脏活检显示肝细胞变性并伴有轻度嗜酸性粒细胞浸润。随着皮质类固醇治疗，肝功能得到改善。
