Khudoleĭ V V, Gvil'dis V Iu, Pliss G B
Vopr Onkol. 1989;35(7):837-42.
Dichlorobromomethane (DCMB) and dibromochloromethane (DBCM) isolated from chlorinated drinking water were tested for toxicity, mutagenicity and carcinogenicity. Both agents proved mutagenic in a "dessicator" modification of the Ames test using Salmonella typhimurium TA98 and TA100 in the presence of exogenous metabolic activation. In aquarium Danio rerio fish tests, LD50/30 was 250 mg/l for both compounds. Both agents induced hepatocellular carcinoma in fish: DCMB--in 11 out of 29 animals (at 16.5 weeks) and DBCM--in 3 out of 16 (at 26.5 weeks). These data merit further investigation of the agents' carcinogenicity in chronic experiments in rodents.
对从氯化饮用水中分离出的二氯溴甲烷（DCMB）和二溴氯甲烷（DBCM）进行了毒性、致突变性和致癌性测试。在使用鼠伤寒沙门氏菌TA98和TA100的Ames试验的“干燥器”改良试验中，在外源代谢活化存在的情况下，这两种物质均被证明具有致突变性。在斑马鱼水族箱试验中，两种化合物的LD50/30均为250 mg/l。这两种物质均在鱼类中诱发了肝细胞癌：DCMB——29只动物中有11只（在16.5周时），DBCM——16只中有3只（在26.5周时）。这些数据值得在啮齿动物的慢性实验中对这些物质的致癌性进行进一步研究。
