Diadyk A I, Vasilenko I V, Shpilevaia N I, Siniachenko O V, Chernykh O S
Vrach Delo. 1989 May(5):69-72.
Data are reported of a clinical and morphological including electron microscopical study of 132 patients with primary diffuse mesangioproliferative glomerulonephritis (DMPGN). A comparison of morphological signs using methods of non-parametric statistics revealed a complex dependence between glomerulosclerosis and sclerosis of the stroma, tubular atrophy and dystrophy; sclerosis of stroma and its cellular infiltration. Comparison of morphological aspects and clinical manifestations of DMPGN allowed to establish that development of disorders of partial functions of the kidneys has a complex genesis as evidenced by dependence of disorders on the presence and severity of glomerulosclerosis, stroma sclerosis, tubular atrophy and frequency of crescents/microcrescents.
报告了对132例原发性弥漫性系膜增生性肾小球肾炎（DMPGN）患者进行的临床和形态学（包括电子显微镜）研究的数据。使用非参数统计方法对形态学特征进行比较，结果显示肾小球硬化与间质硬化、肾小管萎缩和营养不良之间存在复杂的相关性；间质硬化与其细胞浸润之间也存在相关性。对DMPGN的形态学方面和临床表现进行比较后发现，肾脏部分功能障碍的发生具有复杂的成因，这一点从功能障碍对肾小球硬化、间质硬化、肾小管萎缩以及新月体/微新月体频率的存在和严重程度的依赖性中得到了证实。
