Shi M-H, Wu Y, Li L, Cai Y-F, Liu M, Gao X-H, Chen H-D
Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, PR China.
Clin Exp Dermatol. 2017 Jan;42(1):21-29. doi: 10.1111/ced.12950. Epub 2016 Oct 13.
There are conflicting reports on the correlation between vitiligo and the levels of either superoxide dismutase (SOD) or malondialdehyde (MDA).
To clarify the association between vitiligo and SOD or MDA.
Relevant published articles were searched according to our eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% CI.
Patients with either the active or stable vitiligo had higher levels of both SOD (stable: SMD = 1.61, 95% CI 0.66-2.56, P = 0.001; active: SMD = 2.56, 95% CI 1.13-3.99, P < 0.001) and MDA (stable: SMD = 2.70, 95% CI 1.81-3.59, P < 0.001; active: SMD = 3.50, 95% CI 2.29-4.71, P < 0.001), compared with healthy controls.
This meta-analysis showed a significant association between vitiligo and high levels of both SOD and MDA.
关于白癜风与超氧化物歧化酶（SOD）或丙二醛（MDA）水平之间的相关性，存在相互矛盾的报道。
阐明白癜风与SOD或MDA之间的关联。
根据我们的纳入标准检索相关发表文章。进行荟萃分析以汇总标准化均数差（SMD）及其95%置信区间（CI）的估计值。
与健康对照相比，活动期或稳定期白癜风患者的SOD（稳定期：SMD = 1.61，95%CI 0.66 - 2.56，P = 0.001；活动期：SMD = 2.56，95%CI 1.13 - 3.99，P < 0.001）和MDA（稳定期：SMD = 2.70，95%CI 1.81 - 3.59，P < 0.001；活动期：SMD = 3.50，95%CI 2.29 - 4.71，P < 0.001）水平均较高。
该荟萃分析表明白癜风与高水平的SOD和MDA之间存在显著关联。
