Torres Sandra Regina, Pedrazas Carlos Henrique Silva, Correia Marcos Paulo Veloso, Azevedo Mario Newton Leitão de, Zamprogno Thaís, Silva Arley, Gonçalves Lucio Souza, Papi José Angelo de Souza
Universidade Federal do Rio de Janeiro - UFRJ, School of Dentistry and Oral Health Program, Clementino Fraga Filho University Hospital, Department of Oral Pathology and Oral Diagnostic, Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro - UFRJ, Clementino Fraga Filho University Hospital, Department of Internal Medicine, Rio de Janeiro, RJ, Brazil.
Braz Oral Res. 2016 Oct 10;30(1):e106. doi: 10.1590/1807-3107BOR-2016.vol30.0106.
Oral complications of RA may include temporomandibular joint disorders, mucosa alterations and symptoms of dry mouth. The aim of this study was to evaluate the salivary gland function of subjects with rheumatoid arthritis (RA) comparing it to healthy controls. Subjects with other systemic conditions known to affect salivary functions were excluded. A questionnaire was applied for the evaluation of xerostomia. Resting and chewing-stimulated salivary flow rates (SFR) were obtained under standard conditions. There were 145 subjects included of the study (104 RA and 38 controls). About 66.7% of the RA subjects and 2.4% in control group presented xerostomia. The median resting SFR were 0.24 ml/min for RA subjects and 0.40 mL/min for controls (p = 0.04). The median stimulated SFR were 1.31 mL/min for RA subjects and 1.52 ml/min for controls (p = 0.33). No significant differences were found between resting and stimulated SFR of RA subjects not using xerogenic medications and controls. There was significantly higher number of subjects presenting hyposalivation in the RA group than among controls, even when subjects using xerogenic medications were eliminated from the analysis. In conclusion, hyposalivation and xerostomia were more frequent among RA subjects not using xerogenic medication than among controls, although there were no significant differences in the median SFR between groups.
类风湿关节炎（RA）的口腔并发症可能包括颞下颌关节紊乱、黏膜改变和口干症状。本研究的目的是评估类风湿关节炎（RA）患者的唾液腺功能，并与健康对照组进行比较。排除已知会影响唾液功能的其他全身性疾病患者。应用一份问卷来评估口干情况。在标准条件下获取静息和咀嚼刺激后的唾液流速（SFR）。该研究共纳入145名受试者（104名RA患者和38名对照组）。约66.7%的RA受试者和2.4%的对照组受试者出现口干。RA受试者静息SFR的中位数为0.24毫升/分钟，对照组为0.40毫升/分钟（p = 0.04）。RA受试者刺激后SFR的中位数为1.31毫升/分钟，对照组为1.52毫升/分钟（p = 0.33）。未使用致口干药物的RA受试者与对照组在静息和刺激后的SFR方面未发现显著差异。即使在分析中排除使用致口干药物的受试者，RA组出现唾液分泌减少的受试者数量仍显著高于对照组。总之，未使用致口干药物的RA受试者比对照组更频繁出现唾液分泌减少和口干，尽管两组之间SFR的中位数没有显著差异。
