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T4SP数据库2.0：一个经过改进的细菌基因组IV型分泌系统数据库及新的在线分析工具

T4SP Database 2.0: An Improved Database for Type IV Secretion Systems in Bacterial Genomes with New Online Analysis Tools.

作者信息

Han Na, Yu Weiwen, Qiang Yujun, Zhang Wen

机构信息

State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China.

出版信息

Comput Math Methods Med. 2016;2016:9415459. doi: 10.1155/2016/9415459. Epub 2016 Sep 21.

DOI:10.1155/2016/9415459
PMID:27738451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5050370/
Abstract

Type IV secretion system (T4SS) can mediate the passage of macromolecules across cellular membranes and is essential for virulent and genetic material exchange among bacterial species. The Type IV Secretion Project 2.0 (T4SP 2.0) database is an improved and extended version of the platform released in 2013 aimed at assisting with the detection of Type IV secretion systems (T4SS) in bacterial genomes. This advanced version provides users with web server tools for detecting the existence and variations of T4SS genes online. The new interface for the genome browser provides a user-friendly access to the most complete and accurate resource of T4SS gene information (e.g., gene number, name, type, position, sequence, related articles, and quick links to other webs). Currently, this online database includes T4SS information of 5239 bacterial strains. . T4SS is one of the most versatile secretion systems necessary for the virulence and survival of bacteria and the secretion of protein and/or DNA substrates from a donor to a recipient cell. This database on virB/D genes of the T4SS system will help scientists worldwide to improve their knowledge on secretion systems and also identify potential pathogenic mechanisms of various microbial species.

摘要

IV型分泌系统（T4SS）能够介导大分子穿过细胞膜，对于细菌间的毒性和遗传物质交换至关重要。IV型分泌系统项目2.0（T4SP 2.0）数据库是2013年发布平台的改进和扩展版本，旨在协助检测细菌基因组中的IV型分泌系统（T4SS）。这个高级版本为用户提供了在线检测T4SS基因存在和变异的网络服务器工具。基因组浏览器的新界面为用户提供了方便的途径，可获取最完整、准确的T4SS基因信息资源（如基因数量、名称、类型、位置、序列、相关文章以及到其他网站的快速链接）。目前，这个在线数据库包含5239个细菌菌株的T4SS信息。T4SS是细菌毒性和生存以及蛋白质和/或DNA底物从供体细胞向受体细胞分泌所必需的最多功能的分泌系统之一。这个关于T4SS系统virB/D基因的数据库将帮助全球科学家增进对分泌系统的了解，并识别各种微生物物种的潜在致病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/3f446cd3d8b7/CMMM2016-9415459.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/e471fe3a4da8/CMMM2016-9415459.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/bafa44322dc6/CMMM2016-9415459.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/23cfe8b77f97/CMMM2016-9415459.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/3faee1ab3350/CMMM2016-9415459.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/cb67f306e179/CMMM2016-9415459.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/3f446cd3d8b7/CMMM2016-9415459.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/e471fe3a4da8/CMMM2016-9415459.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/bafa44322dc6/CMMM2016-9415459.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/23cfe8b77f97/CMMM2016-9415459.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/3faee1ab3350/CMMM2016-9415459.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/cb67f306e179/CMMM2016-9415459.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c639/5050370/3f446cd3d8b7/CMMM2016-9415459.006.jpg

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2
Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus.IVC 型分泌系统：一种新型的 IV 型分泌系统（T4SS）亚类，常见于革兰阳性链球菌属。
PLoS One. 2012;7(10):e46390. doi: 10.1371/journal.pone.0046390. Epub 2012 Oct 4.
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GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2.
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Using an optimal set of features with a machine learning-based approach to predict effector proteins for Legionella pneumophila.利用基于机器学习的最佳特征集预测嗜肺军团菌的效应蛋白。
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