使用纳米颗粒稳定的纳米胶囊实现细胞质中大蛋白的输送。
Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules.
机构信息
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
出版信息
Nanoscale. 2016 Oct 27;8(42):18038-18041. doi: 10.1039/c6nr07162g.
Abstract
We report an effective intracellular delivery strategy for proteins of high molecular weight using AuNP stabilized capsules. This strategy provides direct delivery to the cytosol, avoiding endosomal entrapment.
摘要
我们报告了一种使用 AuNP 稳定的胶囊实现高分子量蛋白质的有效细胞内递释策略。该策略提供了细胞质的直接递释，避免了内体捕获。
相似文献
1
Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules.使用纳米颗粒稳定的纳米胶囊实现细胞质中大蛋白的输送。
Nanoscale. 2016 Oct 27;8(42):18038-18041. doi: 10.1039/c6nr07162g.
2
Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.使用纳米颗粒稳定的纳米胶囊将功能性蛋白质和酶直接递送至细胞质中。
ACS Nano. 2013 Aug 27;7(8):6667-6673. doi: 10.1021/nn402753y. Epub 2013 Jul 8.
3
Amphiphilic gold nanoparticles displaying flexible bifurcated ligands as a carrier for siRNA delivery into the cell cytosol.展示柔性分叉配体的两亲性金纳米颗粒作为将小干扰RNA递送至细胞质的载体。
ACS Appl Mater Interfaces. 2014 Dec 24;6(24):22146-54. doi: 10.1021/am505577j. Epub 2014 Dec 12.
4
Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules.利用纳米颗粒稳定的纳米胶囊进行胞质蛋白递送对蛋白质向细胞核转运的定量追踪。
Bioconjug Chem. 2015 Jun 17;26(6):1004-7. doi: 10.1021/acs.bioconjchem.5b00141. Epub 2015 Jun 2.
5
Simultaneous cytosolic delivery of a chemotherapeutic and siRNA using nanoparticle-stabilized nanocapsules.使用纳米囊泡稳定的纳米颗粒同时递送达化疗药物和 siRNA 进入细胞质。
Nanotechnology. 2016 Sep 16;27(37):374001. doi: 10.1088/0957-4484/27/37/374001. Epub 2016 Aug 9.
6
Drug delivery using nanoparticle-stabilized nanocapsules.使用纳米颗粒稳定的纳米胶囊进行药物递送。
Angew Chem Int Ed Engl. 2011 Jan 10;50(2):477-81. doi: 10.1002/anie.201005662.
7
Intracellular delivery of proteins by nanocarriers.纳米载体介导的蛋白质细胞内递送
Nanomedicine (Lond). 2017 Apr;12(8):941-952. doi: 10.2217/nnm-2016-0393. Epub 2017 Mar 24.
8
Promises and pitfalls of intracellular delivery of proteins.蛋白质细胞内递送的前景与陷阱
Bioconjug Chem. 2014 Sep 17;25(9):1602-8. doi: 10.1021/bc500320j. Epub 2014 Sep 2.
9
General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering.通过蛋白质-纳米颗粒共工程化实现细胞质内蛋白质的直接递送的一般策略。
ACS Nano. 2017 Jun 27;11(6):6416-6421. doi: 10.1021/acsnano.7b02884. Epub 2017 Jun 15.
10
Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents.合成传递剂介导的大分子的内体逃逸和细胞质渗透。
Bioconjug Chem. 2019 Feb 20;30(2):293-304. doi: 10.1021/acs.bioconjchem.8b00799. Epub 2018 Dec 6.
引用本文的文献
1
Polymersome-based protein drug delivery - quo vadis?基于聚合物囊泡的蛋白药物递送——路在何方？
Chem Soc Rev. 2023 Jan 25;52(2):728-778. doi: 10.1039/d2cs00106c.
2
High affinity protein surface binding through co-engineering of nanoparticles and proteins.通过纳米颗粒和蛋白质的共同工程实现高亲和力蛋白表面结合。
Nanoscale. 2022 Feb 10;14(6):2411-2418. doi: 10.1039/d1nr07497k.
3
Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery.通过纳米载体介导的细胞质蛋白递送来靶向细胞内靶标。
Trends Pharmacol Sci. 2020 Oct;41(10):743-754. doi: 10.1016/j.tips.2020.08.005. Epub 2020 Sep 2.
4
Switchable Fluorescence of Doxorubicin for Label-Free Imaging of Bioorthogonal Drug Release.用于生物正交药物释放无标记成像的阿霉素可切换荧光
ChemMedChem. 2020 Jun 4;15(11):988-994. doi: 10.1002/cmdc.202000065. Epub 2020 Apr 17.
5
Protein Delivery into the Cell Cytosol using Non-Viral Nanocarriers.使用非病毒纳米载体将蛋白质递送到细胞胞质溶胶中。
Theranostics. 2019 May 18;9(11):3280-3292. doi: 10.7150/thno.34412. eCollection 2019.
6
Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies.利用无机纳米颗粒-蛋白质超分子组装体将蛋白质递送入细胞。
Chem Soc Rev. 2018 May 21;47(10):3421-3432. doi: 10.1039/c8cs00008e.
7
General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering.通过蛋白质-纳米颗粒共工程化实现细胞质内蛋白质的直接递送的一般策略。
ACS Nano. 2017 Jun 27;11(6):6416-6421. doi: 10.1021/acsnano.7b02884. Epub 2017 Jun 15.
8
Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags.利用非肽硼酸标签主动靶向细胞核。
J Am Chem Soc. 2017 Jun 28;139(25):8547-8551. doi: 10.1021/jacs.7b02801. Epub 2017 Jun 19.
9
Intracellular delivery of proteins by nanocarriers.纳米载体介导的蛋白质细胞内递送
Nanomedicine (Lond). 2017 Apr;12(8):941-952. doi: 10.2217/nnm-2016-0393. Epub 2017 Mar 24.
本文引用的文献
1
Advances in Anticancer Protein Delivery Using Micro-/ Nanoparticles.使用微/纳米颗粒进行抗癌蛋白递送的进展
Part Part Syst Charact. 2014 Dec;31(12):1204-1222. doi: 10.1002/ppsc.201400140. Epub 2014 Oct 16.
2
DNA-Mediated Cellular Delivery of Functional Enzymes.功能性酶的DNA介导细胞递送
J Am Chem Soc. 2015 Dec 2;137(47):14838-41. doi: 10.1021/jacs.5b09711. Epub 2015 Nov 20.
3
Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers.载体介导的细胞内递送的挑战：超越内涵体屏障。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 May;8(3):465-78. doi: 10.1002/wnan.1377. Epub 2015 Nov 5.
4
Antibody-drug conjugates as novel anti-cancer chemotherapeutics.抗体药物偶联物作为新型抗癌化疗药物。
Biosci Rep. 2015 Jun 12;35(4):e00225. doi: 10.1042/BSR20150089.
5
Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules.利用纳米颗粒稳定的纳米胶囊进行胞质蛋白递送对蛋白质向细胞核转运的定量追踪。
Bioconjug Chem. 2015 Jun 17;26(6):1004-7. doi: 10.1021/acs.bioconjchem.5b00141. Epub 2015 Jun 2.
6
Cell surface-based sensing with metallic nanoparticles.基于金属纳米颗粒的细胞表面传感。
Chem Soc Rev. 2015 Jul 7;44(13):4264-4274. doi: 10.1039/c4cs00387j. Epub 2015 Apr 8.
7
Integration of drug, protein, and gene delivery systems with regenerative medicine.药物、蛋白质和基因递送系统与再生医学的整合。
Drug Deliv Transl Res. 2015 Apr;5(2):168-86. doi: 10.1007/s13346-013-0165-8.
8
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.阳离子脂质介导的蛋白质递送能够在体外和体内实现高效的基于蛋白质的基因组编辑。
Nat Biotechnol. 2015 Jan;33(1):73-80. doi: 10.1038/nbt.3081. Epub 2014 Oct 30.
9
Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB.将一种酶-IGFII融合蛋白递送至小鼠大脑对IIIB型黏多糖贮积症具有治疗作用。
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14870-5. doi: 10.1073/pnas.1416660111. Epub 2014 Sep 29.
10
Stimuli-responsive nanomaterials for therapeutic protein delivery.用于治疗性蛋白质递送的刺激响应性纳米材料。
J Control Release. 2014 Nov 28;194:1-19. doi: 10.1016/j.jconrel.2014.08.015. Epub 2014 Aug 21.
Zotero 插件