Ray Moumita, Lee Yi-Wei, Scaletti Federica, Yu Ruijin, Rotello Vincent M
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Nanomedicine (Lond). 2017 Apr;12(8):941-952. doi: 10.2217/nnm-2016-0393. Epub 2017 Mar 24.
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue. In this review we discuss recent trends in protein delivery using nanocarriers, focusing on the ability of these strategies to deliver protein into the cytosol.
蛋白质的细胞内递送可能是一种改变治疗方法的途径。然而，对于大多数应用而言，蛋白质需要进入细胞质才能发挥作用。人们已经开发出各种各样的蛋白质递送策略，但是在不产生急性细胞毒性的情况下将递送的蛋白质输送到细胞质中仍然是一个关键问题。在这篇综述中，我们讨论了使用纳米载体进行蛋白质递送的最新趋势，重点关注这些策略将蛋白质递送至细胞质的能力。
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