利用无机纳米颗粒-蛋白质超分子组装体将蛋白质递送入细胞。
Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies.
机构信息
Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, USA.
出版信息
Chem Soc Rev. 2018 May 21;47(10):3421-3432. doi: 10.1039/c8cs00008e.
Abstract
The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that range from direct assembly, encapsulation and composite formation. We will discuss factors that affect the efficacy of nanoassemblies for delivery from the perspective of both nanoparticles and proteins. Challenges in the field, particularly achieving effective cytosolar protein delivery through endosomal escape or evasion are discussed.
摘要
蛋白质递送至细胞内是一个具有广泛治疗应用潜力的领域，包括癌症治疗、免疫调节和遗传性疾病治疗。在这篇综述中，我们介绍了最近开发的用于蛋白质递送的纳米组装体，这些组装体利用了从直接组装、封装和复合形成等多种策略。我们将从纳米颗粒和蛋白质两个角度讨论影响纳米组装体递送效果的因素。讨论了该领域的挑战，特别是通过内体逃逸或逃避实现有效的细胞质蛋白递送。
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