USPIO size control through microwave nonaqueous sol-gel method for neoangiogenesis T MRI contrast agent.

作者信息

Richard Sophie, Eder Véronique, Caputo Gianvito, Journé Clément, Ou Phalla, Bolley Julie, Louedec Liliane, Guenin Erwann, Motte Laurence, Pinna Nicola, Lalatonne Yoann

机构信息

Laboratoire CSPBAT, CNRS UMR 7244, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, F-93017 Bobigny, France.

Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, 74 rue M. Cachin, F-93017 Bobigny, France.

出版信息

Nanomedicine (Lond). 2016 Nov;11(21):2769-2779. doi: 10.2217/nnm-2016-0177. Epub 2016 Oct 14.

AIM

Tunable size ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles from 3 to 9 nm coated with polyethylene glycol phosphonate moieties have been designed for neovascularization MRI.

MATERIALS & METHODS: USPIO were synthesized using a nonaqueous sol-gel method. An ischemia-reperfusion rat model has been chosen for neo-angiogenesis and scanned on MRI after injection of different sized USPIO. Histological studies have been performed for USPIO localization within the tissue.

RESULTS

The magnetic properties and consequently their MRI relaxivities are drastically dependent on the crystalline core size. In vivo MRI spots were observed specifically in the ischemic area. The best MRI contrast within neovascularization is generated by 6 nm nanoparticles proving that compromise between T relaxivity and physico-chemical properties is essential for the design of effective MRI contrast agent.