在传统和脉冲X射线辐照条件下氧化铁固定化药物模拟报告分子的合成与活化

Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions.

作者信息

Barosi Anna, Dunkel Petra, Guénin Erwann, Lalatonne Yoann, Zeitoun Philippe, Fitton Isabelle, Journé Clément, Bravin Alberto, Maruani Antoine, Dhimane Hamid, Motte Laurence, Dalko Peter I

机构信息

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, UMR 8601 45, Rue des Saints-Pères 75210 Paris France

Laboratory for Vascular Translational Sciences (LVTS), INSERM, U1148, Université Paris 13 74 Rue Marcel Cachin, 93017 Bobigny France

出版信息

RSC Adv. 2020 Jan 21;10(6):3366-3370. doi: 10.1039/c9ra09828c. eCollection 2020 Jan 16.

An efficient nano-sized delivery system is presented here allowing the immobilized, picolinium-tethered organic ligand to be released by X-ray irradiation. A marked difference was observed in the fragmentation efficiency by using conventional Cs-137 pulsed sources.