Park Jae-Min, Lee Jee-Yon, Dong Jae June, Lee Duk-Chul, Lee Yong-Jae
J Pediatr Endocrinol Metab. 2016 Nov 1;29(11):1259-1265. doi: 10.1515/jpem-2016-0244.
Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance. However, few studies have examined the association between TG/HDL-C and insulin resistance in the general adolescent population. This study aimed to examine the association between TG/HDL-C and insulin resistance in a nationally representative sample of Korean adolescents.
A total of 2649 participants aged 12-18 years were selected from the 2007 to 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Insulin resistance was defined as the homeostatic model assessment of insulin resistance (HOMA-IR) values greater than the 80th percentile.
The mean values of most cardiometabolic variables increased proportionally with TG/HDL-C quartiles. Compared to individuals in the lowest TG/HDL-C quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.91 in boys and 2.38 in girls after adjusting for confounding variables.
This study suggests that TG/HDL-C could be a convenient marker for identifying Korean adolescents with insulin resistance.
研究表明甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）可作为胰岛素抵抗的替代指标。然而，很少有研究探讨普通青少年人群中TG/HDL-C与胰岛素抵抗之间的关联。本研究旨在调查韩国青少年全国代表性样本中TG/HDL-C与胰岛素抵抗之间的关联。
从2007年至2010年韩国国家健康与营养检查调查（KNHANES）中选取了2649名年龄在12至18岁之间的参与者。胰岛素抵抗定义为胰岛素抵抗稳态模型评估（HOMA-IR）值高于第80百分位数。
大多数心血管代谢变量的平均值随TG/HDL-C四分位数成比例增加。在校正混杂变量后，与TG/HDL-C最低四分位数的个体相比，最高四分位数个体的胰岛素抵抗比值比在男孩中为2.91，在女孩中为2.38。
本研究表明，TG/HDL-C可能是识别有胰岛素抵抗的韩国青少年的便捷指标。
