Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2012 Jul;97(1):132-8. doi: 10.1016/j.diabres.2012.04.022. Epub 2012 May 18.
This study explores the association between the ratio of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) and insulin resistance according to waist circumference in the general Korean population.
7623 participants were selected from the Korean National Health and Nutrition Examination Survey (KNHANES) conducted during 2007-2009 and included in this cross-sectional study. Insulin resistance was defined as the values equal to or greater than the 75th percentile of the homeostasis model assessment of insulin resistance (HOMA-IR).
Positive correlation was found between the ratio of TG and HDL-C and other variables such as waist circumference, total cholesterol, and HOMA-IR for both men and women. The odds ratios (ORs) (95% confidence interval) for insulin resistance for the highest quartile of TG/HDL-C were 2.48 in men and 3.05 in women. The significant relationship between the TG/HDL-C ratio and insulin resistance was not only maintained across all quartiles of waist circumference but also seemed to be enhanced in the higher quartiles of waist circumference.
In the general Korean population, there seems to be a linear association between TG/HDL-C ratio and insulin resistance, regardless of degrees of waist circumference.
本研究旨在探讨在韩国普通人群中，根据腰围，甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）比值与胰岛素抵抗之间的关系。
本横断面研究选取了 2007-2009 年韩国国家健康与营养调查（KNHANES）中的 7623 名参与者。胰岛素抵抗定义为稳态模型评估的胰岛素抵抗（HOMA-IR）的第 75 百分位数或更高的值。
无论男女，TG 与 HDL-C 比值与腰围、总胆固醇和 HOMA-IR 等其他变量呈正相关。男性 TG/HDL-C 最高四分位数的胰岛素抵抗比值比（OR）（95%置信区间）为 2.48，女性为 3.05。TG/HDL-C 比值与胰岛素抵抗之间的显著关系不仅在所有腰围四分位数中保持不变，而且在腰围较高四分位数中似乎也有所增强。
在韩国普通人群中，无论腰围程度如何，TG/HDL-C 比值与胰岛素抵抗之间似乎存在线性关联。
