Sikora Justyna, Smycz-Kubańska Marta, Mielczarek-Palacz Aleksandra, Kondera-Anasz Zdzisława
Department of Immunology and Serology, Sosnowiec School of Pharmacy with the Division of Medical Analytics in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Am J Reprod Immunol. 2017 Apr;77(4). doi: 10.1111/aji.12622. Epub 2017 Jan 25.
Endometriosis is a chronic inflammatory disease associated with an impairment in immune response. Disorders in the peritoneal fluid and ectopic endometrium macrophage populations and their secretory products create a specific microenvironment inducing the development of the disease. The important factors involved in inflammation associated with endometriosis are chemokines, especially interleukin (IL)-8. For this reason, the current study briefly reviews the role of IL-8 in the pathogenesis of endometriosis.
A systematic review was done on all published studies that compared IL-8 expression and concentration in patients with and without endometriosis to evaluate their potential as biomarkers for the disease.
IL-8 induces chemotaxis of neutrophils and other immune cells; also, it is a potent angiogenic agent. Most researchers pointed to the increased peritoneal and serum IL-8 levels and showed correlation with the severity of the disease, size and number of the active lesions. IL-8 takes part in all processes during the development of the disease: adhesion, invasion, and implantation of ectopic tissue. Additionally, the chemokine plays a role in growth and maintenance of ectopic endometrial tissue directly affecting endometrial cell proliferation. IL-8 might also protect ectopic cells against death by apoptosis.
It may act as an autocrine growth factor in the endometrium and promotes the vicious circle of endometrial cell attachment and, in consequence, may lead to a transformation from acute to chronic inflammation stage.
子宫内膜异位症是一种与免疫反应受损相关的慢性炎症性疾病。腹腔液和异位子宫内膜巨噬细胞群体及其分泌产物的紊乱会形成一种特定的微环境，从而诱发该疾病的发展。与子宫内膜异位症相关的炎症中涉及的重要因素是趋化因子，尤其是白细胞介素（IL）-8。因此，本研究简要回顾了IL-8在子宫内膜异位症发病机制中的作用。
对所有已发表的研究进行系统综述，这些研究比较了患有和未患有子宫内膜异位症的患者中IL-8的表达和浓度，以评估其作为该疾病生物标志物的潜力。
IL-8可诱导中性粒细胞和其他免疫细胞的趋化作用；此外，它还是一种强效血管生成剂。大多数研究人员指出，腹腔液和血清中IL-8水平升高，并表明其与疾病严重程度、活性病灶的大小和数量相关。IL-8参与了疾病发展过程中的所有环节：异位组织的黏附、侵袭和植入。此外，这种趋化因子在异位子宫内膜组织的生长和维持中发挥作用，直接影响子宫内膜细胞增殖。IL-8还可能保护异位细胞免于凋亡死亡。
它可能作为子宫内膜中的自分泌生长因子，促进子宫内膜细胞黏附的恶性循环，进而可能导致从急性炎症阶段转变为慢性炎症阶段。
