乙型肝炎与非肝细胞癌恶性肿瘤风险。

Hepatitis B and Risk of Non-Hepatocellular Carcinoma Malignancy.

机构信息

Gastroenterology Fellowship Program, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA.

Gastroenterology Fellowship Program, Cedars Sinai Medical Center, Geffen School of Medicine at University of California Los Angeles, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA.

出版信息

Clin Liver Dis. 2016 Nov;20(4):693-702. doi: 10.1016/j.cld.2016.06.005. Epub 2016 Aug 31.

DOI:10.1016/j.cld.2016.06.005

PMID:27742008

Abstract

Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.

摘要

慢性乙型肝炎感染 (CHB) 是恶性肿瘤的已知危险因素。与肝细胞癌 (HCC) 不同，人们对非 HCC 恶性肿瘤的风险了解较少。然而，流行病学和病理证据表明非霍奇金淋巴瘤与 CHB 之间存在很强的关联。关于其他恶性肿瘤（如胰腺腺癌和肝内胆管癌）风险的数据则存在差异。对这些患者的感染和恶性肿瘤进行监测和适当治疗至关重要。需要进一步研究这些关联，这可能会为这些疾病的发病机制和治疗带来新的见解。