年龄和可的松治疗对幼鼠两种肠道溶酶体水解酶的影响。
Influence of age and cortisone treatment on two intestinal lysosomal hydrolases in young rats.
作者信息
Baglioni T, Locatelli A, Sartorelli P, Simonic T
出版信息
Ital J Biochem. 1978 Jan-Feb;27(1):1-10.
The effects of cortisone acetate injected i.p. on acid phosphatase and beta-glucuronidase in the small intestine mucosa of two groups of rats aging 12-14 and 20-22 days are reported. The following results are obtained: a) Total and free activities of the two enzymes show age-dependent differences. b) Cortisone acetate causes a very marked decrease of the enzymic activities only in the younger rats while being ineffective on the older ones. c) The kinetics of the enzyme release at 37 degrees C appear independent either of age or of cortisone injection. d) The "in vitro" lysosome labilizing treatments are ineffective.
报道了腹腔注射醋酸可的松对两组分别为12 - 14日龄和20 - 22日龄大鼠小肠黏膜酸性磷酸酶和β - 葡萄糖醛酸酶的影响。得到以下结果：a) 两种酶的总活性和游离活性呈现年龄依赖性差异。b) 醋酸可的松仅使较年幼大鼠的酶活性显著降低，而对较年长大鼠无效。c) 37℃时酶释放的动力学似乎与年龄或可的松注射无关。d) “体外”溶酶体不稳定化处理无效。
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