Aepfelbacher Martin, Wolters Manuel
Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Curr Top Microbiol Immunol. 2017;399:201-220. doi: 10.1007/82_2016_33.
Pathogenic bacteria of the genus Yersinia include Y. pestis-the agent of plaque-and two enteropathogens, Y. enterocolitica, and Y. pseudotuberculosis. These pathogens have developed an array of virulence factors aimed at manipulating Rho GTP-binding proteins and the actin cytoskeleton in host cells to cross the intestinal barrier and suppress the immune system. Yersinia virulence factors include outer membrane proteins triggering cell invasion by binding to integrins, effector proteins injected into host cells to manipulate Rho protein functions and a Rho protein-activating exotoxin. Here, we present an overview of how Yersinia and host factors are integrated in a regulatory network that orchestrates the subversion of host defense.
耶尔森氏菌属的病原菌包括鼠疫耶尔森氏菌（引发鼠疫的病原体）以及两种肠道病原体，即小肠结肠炎耶尔森氏菌和假结核耶尔森氏菌。这些病原体已形成一系列毒力因子，旨在操纵宿主细胞中的Rho GTP结合蛋白和肌动蛋白细胞骨架，以穿过肠道屏障并抑制免疫系统。耶尔森氏菌毒力因子包括通过与整合素结合触发细胞入侵的外膜蛋白、注入宿主细胞以操纵Rho蛋白功能的效应蛋白以及一种Rho蛋白激活外毒素。在此，我们概述了耶尔森氏菌和宿主因子如何整合到一个协调宿主防御颠覆的调控网络中。
