Miyata Kanjiro
Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo.
Drug Discov Ther. 2016 Nov 28;10(5):236-247. doi: 10.5582/ddt.2016.01061. Epub 2016 Oct 17.
In recent decades, nucleic acid therapeutics have been attracting much attention because of their potential as treatments for various diseases that require high target specificity. Nevertheless, the number of approved nucleic acid drugs is very limited due to substantially poor bioavailability, thereby generating the need for nucleic acid delivery carriers. A variety of delivery formulations have been reported so far. This review particularly describes polymer-based delivery carriers for systemic administration, highlighting the potential of biological environment-responsive chemistry for overcoming the biological barriers to nucleic acid delivery.
近几十年来，核酸疗法因其作为治疗各种需要高靶向特异性疾病的潜力而备受关注。然而，由于生物利用度极低，获批的核酸药物数量非常有限，因此需要核酸递送载体。迄今为止，已经报道了多种递送制剂。本综述特别描述了用于全身给药的基于聚合物的递送载体，强调了生物环境响应化学在克服核酸递送生物屏障方面的潜力。
