Shukla V K, Sethi A K, Garg S K, Ganguly N K, Kulkarni S K
Department of Pharmaceutical Sciences, Panjab University, Chandigarh India.
Arch Int Pharmacodyn Ther. 1989 May-Jun;299:127-33.
Venoruton offers a protection against hypoxic stress-induced neurotoxicity (convulsions and death) in mice. It also inhibits free radical generation, since it produces a concentration-dependent (5-160 micrograms/10(6) cells/ml) decrease of chemiluminescence response from human neutrophils. The maximum inhibition was observed at 140 micrograms/10(6) cells/ml. The in vivo protective effect against hypoxic stress-induced neurotoxicity has been correlated to the inhibitory action of venoruton on oxygen free radical generation.
维脑路通对小鼠低氧应激诱导的神经毒性（惊厥和死亡）具有保护作用。它还能抑制自由基的产生，因为它会使人类中性粒细胞的化学发光反应呈浓度依赖性（5 - 160微克/10⁶细胞/毫升）降低。在140微克/10⁶细胞/毫升时观察到最大抑制作用。维脑路通对低氧应激诱导的神经毒性的体内保护作用与它对氧自由基产生的抑制作用相关。
