Zabihi Narges Amel, Pirro Matteo, Johnston Thomas P, Sahebkar Amirhossein
Neurogenic Inflammation Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
Curr Pharm Des. 2017;23(7):969-982. doi: 10.2174/1381612822666161010115235.
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease. NAFLD is considered a multifactorial disease and a clinically relevant hepatic manifestation of metabolic syndrome. NAFLD is often accompanied by a constellation of metabolic and non-metabolic alterations, like dyslipidemia, insulin resistance in the liver and peripheral tissues, inflammation and oxidative stress; therefore, treatment of NAFLD should be directed at correcting all of these disturbances. The natural polyphenol curcumin has been the subject of increasing research for the treatment of NAFLD due to its lipid-modifying, antioxidant, anti-inflammatory, insulinsensitizing, anti-steatotic, and anti-fibrotic properties. The therapeutic efficacy of curcumin has been demonstrated in several experimental models of NAFLD, however, clinical evidence is still scarce. The present review summarizes the current knowledge on the impact of curcumin supplementation on different biochemical and histopathological features of NAFLD.
非酒精性脂肪性肝病（NAFLD）是最常见的肝脏疾病类型。NAFLD被认为是一种多因素疾病，是代谢综合征在临床上相关的肝脏表现。NAFLD常伴有一系列代谢和非代谢改变，如血脂异常、肝脏和外周组织的胰岛素抵抗、炎症和氧化应激；因此，NAFLD的治疗应针对纠正所有这些紊乱。天然多酚姜黄素因其具有调节脂质、抗氧化、抗炎、胰岛素增敏、抗脂肪变性和抗纤维化特性，已成为治疗NAFLD的研究热点。姜黄素的治疗效果已在几种NAFLD实验模型中得到证实，然而，临床证据仍然匮乏。本综述总结了目前关于补充姜黄素对NAFLD不同生化和组织病理学特征影响的知识。
