Kupfer D J, Frank E, Perel J M
Department of Psychiatry, University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
Arch Gen Psychiatry. 1989 Sep;46(9):771-5. doi: 10.1001/archpsyc.1989.01810090013002.
Two key questions regarding the treatment of depression remain unanswered: whether early treatment intervention will shorten the length of the episode and whether a previously successful treatment will be associated with a more rapid response when administered during the subsequent episode. A group of 45 patients with recurrent major depression treated with combined pharmacotherapy and psychotherapy in a similar fashion for two consecutive episodes showed comparable mean times to stabilization of between 11 and 12 weeks. However, the early intervention in the second treatment episode significantly shortened the overall length of the depressive episode by approximately 4 to 5 months.
早期治疗干预是否会缩短发作时长，以及先前成功的治疗方法在后续发作时使用是否会带来更快的反应。一组45名复发性重度抑郁症患者连续两个发作期以类似方式接受药物治疗与心理治疗相结合的治疗，结果显示平均稳定时间相当，在11至12周之间。然而，第二次治疗发作期的早期干预显著缩短了抑郁发作的总时长，缩短了约4至5个月。
