Li Jian-Song, Du Min-Na, Zhang Hui, Zhang Ji, Zhang Shao-Yong, Wang Hai-Yan, Chen An-Liang, Wang Ji-Dong, Xiang Wen-Sheng
a Life Science and Biotechnology Research Center, School of Life Science , Northeast Agricultural University , Harbin , China.
c Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou , China.
Nat Prod Res. 2017 Apr;31(7):780-784. doi: 10.1080/14786419.2016.1244194. Epub 2016 Oct 16.
Two new milbemycin derivatives, 27-methoxylmilbemycin α (1) and 27-oxomilbemycin α (2), were isolated from the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by 1D NMR, 2D NMR and HR-ESI-MS spectral analysis, and comparison with previous reports. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.
从基因工程菌株冰城链霉菌BCJ60中分离出两种新的米尔倍霉素衍生物，27-甲氧基米尔倍霉素α（1）和27-氧代米尔倍霉素α（2）。通过一维核磁共振、二维核磁共振和高分辨电喷雾电离质谱光谱分析，并与先前的报道进行比较，确定了它们的结构。分别针对朱砂叶螨和松材线虫评估了化合物1和2的杀螨和杀线虫能力。结果表明，这两种新的大环内酯1和2具有强大的杀螨和杀线虫活性。
