来自基因工程菌株的两种新米尔倍霉素衍生物。
Two new milbemycin derivatives from a genetically engineered strain .
作者信息
Li Jian-Song, Qi Huan, Zhang Shao-Yong, Xiang Wen-Sheng, Zhang Li-Qin, Wang Hai-Yan, Hao Zhi-Kui, Wang Ji-Dong
机构信息
Institute of Applied Biotechnology, School of Medicine and Pharmaceutical Engineering, Taizhou Vocational and Technical College, Taizhou 318000, China.
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China.
出版信息
J Asian Nat Prod Res. 2021 Jul;23(7):660-665. doi: 10.1080/10286020.2020.1783656. Epub 2020 Jul 1.
Two new milbemycin derivatives, milbemycin M () and milbemycin N (), were isolated from the culture of a genetically engineered strain BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. The acaricidal and nematicidal activities of them against and were tested. The results showed that compounds - possessed potent acaricidal and nematocidal activities.
从基因工程菌株BCJ60的培养物中分离出两种新的米尔倍霉素衍生物，米尔倍霉素M（）和米尔倍霉素N（）。通过对核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）光谱数据的解析以及与先前报道的比较，阐明了它们的结构。测试了它们对和的杀螨活性和杀线虫活性。结果表明，化合物 - 具有强大的杀螨和杀线虫活性。
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