Carr Tara F
Department of Medicine, Banner-University of Arizona Medical Center, Tucson, AZ.
Top Magn Reson Imaging. 2016 Dec;25(6):265-268. doi: 10.1097/RMR.0000000000000108.
The aim of this paper was to review the classification of adverse drug reactions, highlight the known pathophysiology of immediate hypersensitivity reactions, and discuss the utility of diagnostic testing for immunologically mediated immediate reactions to gadolinium-based contrast agents (GBCAs).
Current literature on immediate reactions to GBCA was reviewed and summarized.
Adverse drug reactions to GBCA are rare, and can be attributed to physiologic, immunologic, and nonimmunologic processes. When immunologic reaction is suspected, particularly in the case of severe reactions, skin testing may be useful to confirm allergy and identify alternative agents for subsequent studies.
As GBCAs are widely used for the diagnosis and monitoring of disease, the incidence of adverse drug reactions to GBCA warrants ongoing development of approaches to diagnosis and avoidance of these adverse events.
本文旨在回顾药物不良反应的分类，突出速发型超敏反应已知的病理生理学，并讨论针对基于钆的造影剂（GBCAs）免疫介导的速发型反应的诊断检测的实用性。
对当前关于GBCA速发型反应的文献进行了回顾和总结。
GBCA的药物不良反应罕见，可归因于生理、免疫和非免疫过程。当怀疑有免疫反应时，特别是在严重反应的情况下，皮肤试验可能有助于确认过敏并识别后续研究的替代药物。
由于GBCAs被广泛用于疾病的诊断和监测，GBCA药物不良反应的发生率值得不断开发诊断和避免这些不良事件的方法。
